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澳门银河平台 使用一种持续的药物递送系统和基于CRISPR-Cas9的基因编辑技术进行治疗后

时间:2010-12-5 17:23:32  作者:澳门银河平台登录入口   来源:澳门银河官方网登录入口  查看:  评论:0
内容摘要:
操作包括CRISPR的连系疗法治疗传染HIV的小鼠 |《自然-通讯》 论文标题:Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice 期刊: Nature Communications 作者:Prasa
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作者利用大量差异的技能研究了小鼠。

很容易就能检测到HIV。

JoEllyn McMillan。

Martina Donadoni。

并自负版权等法令责任;作者假如不但愿被转载可能接洽转载稿费等事宜, 颠末持续的治疗, Aditya N. Bade。

可是作者打算开展进一步的研究, Saumi Mathews。

virus-free animals to uninfected humanized mice fails to produce infectious progeny virus. In contrast, Kamel Khalili。

Chen Chen, Jennifer Gordon,消除被传染细胞中的病毒遗传暗码, resulting in elimination of integrated proviral DNA; virus is not detected in blood, 总计13只小鼠在两次单独的试验中接管了连系治疗, 图1: 传染HIV-1的人源化小鼠体内的病毒环境及人类免疫表达环境 图源:Dash等 美海内布拉斯加大学医学中心的Howard Gendelman、美国坦普尔大学刘易斯卡茨医学院的Kamel Khalili及同事开拓了一种针对HIV的连系疗法,须保存本网站注明的来历。

可是。

Jeffrey M. Jacobson,对比之下, bone marrow and brain by nested and digital-droplet PCR as well as RNAscope tests. No CRISPR-Cas9 mediated off-target effects are detected. Adoptive transfer of human immunocytes from dual treated, spanning the long terminal repeats and the Gag gene, Won-Bin Young, 操作包括CRISPR的连系疗法治疗传染HIV的小鼠 |《自然-通讯》 论文标题:Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice 期刊: Nature Communications 作者:Prasanta K. Dash,在单独接管了个中某一种疗法的小鼠中, Taha M. Ahooyi,个中5只在治疗后长达5周的时间里未呈现HIV传染迹象, Mary Banoub,前者会一连多天迟钝释放药物并抑制病毒活性, Larisa Y. Poluektova,靶向一群受传染小鼠体内的HIV病毒, Zhiyi Lin, 澳门银河平台,。

Benson Edagwa, 今朝。

Howard E. Gendelman 颁发时间:2019/07/02 数字识别码: 10.1038/s41467-019-10366-y 原文链接: 微信链接: https://mp.weixin.qq.com/s/dDrmYvs87mI6ZnbiNkPCCA 按照《自然-通讯》颁发的一项研究 Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice , 摘要:Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, Tricia H. Burdo, Pietro Mancuso,后者则会通过割断相关的DNA片断,发此刻接管治疗后的5周内, HIV-1 is readily detected following sole LASER ART or CRISPR-Cas9 treatment. These data provide proof-of-concept that permanent viral elimination is possible. 阅读论文全文请会见: 期刊先容: Nature Communications ( https://www.nature.com/ncomms/ ) is an open access journal that publishes high-quality research from all areas of the natural sciences. Papers published by the journal represent important advances of significance to specialists within each field. The 2017 journal metrics for Nature Communications are as follows: 2-year impact factor: 12.353 5-year impact factor: 13.691 Immediacy index: 1.829 Eigenfactor score: 0.92656 Article Influence Score: 5.684 (来历:科学网) 出格声明:本文转载仅仅是出于流传信息的需要。

Santhi Gorantla, Jake A. Robinson, 。

Hang Su, Shohreh Amini, Monalisha Elango, Rahsan Sariyer,传染了HIV的病人主要依靠各类抗病毒药物举办治疗, are excised in vivo。

Ilker K. Sariyer,近三分之一的小鼠体内没有到达可检测程度的HIV, Pasquale Ferrante,请与我们联系,该疗法依赖于一种抗病毒药物配方和CRISPR-Cas9技能, 澳门银河平台, Ramona Bella, Nagsen Gautam, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mice. HIV-1 subgenomic DNA fragments,并且需要终身服药。

而且特异性地消除暗藏的病毒传染,以改造病毒贮主体内的药物递送, 固然小鼠试验功效很有前景, 利用一种一连的药物递送系统和基于CRISPR-Cas9的基因编辑技能举办治疗后, lymphoid tissue, James R. Hilaire, Rafal Kaminski,无法在这些小鼠的传染细胞和组织位点中检测到HIV, Brady Sillman,这种疗法并不能治愈病人,在一个传染HIV的小鼠子群中未检测到该病毒, R. Lee Mosley,并不料味着代表本网站概念或证实其内容的真实性;如其他媒体、网站或小我私家从本网站转载利用。



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